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By Valentin Fuster MD PhD, Eric J. Topol MD, Elizabeth G. Nabel MD

Written by way of the world’s most advantageous specialists, this quantity offers accomplished assurance of present methods to the prevention, prognosis, and administration of atherothrombosis and its coronary and noncoronary issues. This variation has been completely up-to-date, sharply involved in scientific info, and trimmed to at least one workable volume.

Coverage starts with a assessment of chance components and prevention, emphasizing lipid abnormalities, high blood pressure, smoking, diabetes, and weight problems. next sections study the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, persistent good angina, and noncoronary atherothrombosis. medical shows, clinical administration, and the newest interventional suggestions are included.

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Extra info for Atherothrombosis and coronary artery disease

Example text

As a result, the attributable risk and the potential benefit of treatment increases with age (11). In the elderly, average total and atherogenic LDL-cholesterol often are unacceptable and are greater in women than men.

Specific remedies for angina would not be introduced for more than a century. Heberden remained interested in angina. His book Commentaries on the History and Cure of Diseases, published posthumously in 1802, included additional observations on FIG. 1–5. Edward Jenner (1749–1823). Best known for introducing vaccination, this British physician was the first to attribute angina pectoris to coronary artery disease. (From the collection of W. ) GW_Fuster_CH001_0001-0014 9/23/04 12:42 PM Page 8 8 / CHAPTER 1 had the disorder.

Bath, England: R. Cruttwell, 1799. 29. Burns A. Observations on some of the most frequent and important diseases of the heart. Edinburgh: Bryce & Co, 1809. 30. Fye WB. T. Lauder Brunton and amyl nitrite: a Victorian vasodilator. Circulation 1986;74:222–229. 31. Fye WB. Nitroglycerin: a homeopathic remedy. Circulation 1986;73: 21–29. 32. Fye WB. The delayed diagnosis of acute myocardial infarction: it took half a century. Circulation 1985;72:262–271. 33. Fye WB, ed. Classic papers on coronary thrombosis and myocardial infarction.

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